Ion channel is the basis of bioelectrical activity. It is a specific structure composed of proteins on the cell membrane, which allows different metal or non-metal ions to enter and flow out of cells, whether animals or plants, unicellular organisms or multicellular organisms, without - without ion channels. It plays an important role in the regulation of cell excitation, transmitter release, gland secretion, muscle movement, division, reproduction, maintaining constant cell volume and stable internal environment.

Nerve cells, muscle cells and glandular cells in various tissues of animals have high excitability. Excitable cells show a series of reversible electrical changes when stimulated by dopamine. These electrical changes are the key or decisive factors for excited cells to realize some important functions. Using electrophysiological technology, when drugs act, we can clarify the mechanism of biological electricity generation, monitor the relationship between electrical changes and cell function at the cellular or subcellular level, and then clarify the mechanism of drug action, so as to provide help for drug research and development, screening and optimization.

The biotechnology team of qianzhaoxin can provide customers with routine electrophysiological detection and analysis, intracellular micro fluorescence measurement of free calcium concentration, membrane capacitance monitoring, carbon fiber electrode recording secretion and other services.

[platform cooperation]

Molecular biology, cell biology, pathological staining detection, cell knockout / knock-in, model and transgenic animals, SPF animal conservation, immunological detection, imaging detection, primary culture, cell drug screening, CRISPR / cas9 gene editing, microarray, high-throughput sequencing, leucomics, metabolomics, high-throughput high-content screening, pharmacodynamic evaluation, pharmacological and toxicological experiments, lentivirus packaging and establishment of stable transgenic strains SiRNA and nano drug loading, chip, CO IP, bioinformatics analysis, intellectual property services!