Automated patch clamp technique
inputtime:2020-08-07 hit:


Ion channel is the basis of bioelectrical activity. It is a specific structure composed of proteins on the cell membrane, which allows different metal or non-metal ions to enter and flow out of cells, whether animals or plants, unicellular organisms or multicellular organisms, without - without ion channels. It plays an important role in the regulation of cell excitation, transmitter release, gland secretion, muscle movement, division, reproduction, maintaining constant cell volume and stable internal environment.
Qianzhaoxinye biology has a professional technical team, and cooperates with well-known pharmaceutical enterprises and biotechnology companies at home and abroad to carry out new drug R & D and drug screening, providing customers with new drug R & D and screening services covering a variety of targets and disease fields, including active compound discovery, target verification, lead compound optimization and preclinical candidate drug selection.

Single channel current recording technology, That is, patch clamp technology is the gold standard for ion channel research "It has the advantages of abundant information, high sensitivity, false negative and false positive rate. It is not only suitable for animal cells but also for plant cells, which is a direct research tool to study the mechanism of opening, closing, dynamics, selectivity and permeability of biological membrane ion channels, and extends the scope of traditional electrophysiological research. The application of patch clamp technology has revealed diseases of heart disease, diabetes and epilepsy on molecular level. It has assisted in the screening of many new drugs and clarified the mechanism of action of drugs.


Qianzhaoxinye biological patch clamp screening platform has qpatch-16 screening I workstation, which provides multi-style recording modes such as cell attachment, whole cell, inside out and outside out. It can conduct medium flux screening (MTS) and analyze about 1000 sample data per working day. It provides customers with services such as the primary and secondary screening of various ion channel drugs, the discovery and optimization of leading platform substances, drug safety evaluation, drug target positioning and so on.
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Molecular biology, cell biology, pathological staining detection, cell knockout / knock-in, model and transgenic animals, SPF animal conservation, immunological detection, imaging detection, primary culture, cell drug screening, CRISPR / cas9 gene editing, microarray, high-throughput sequencing, leucomics, metabolomics, high-throughput high-content screening, pharmacodynamic evaluation, pharmacological and toxicological experiments, lentivirus packaging and establishment of stable transgenic strains SiRNA and nano drug loading, chip, CO IP, bioinformatics analysis, intellectual property services!



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